3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-amine (83255-86-1)

Ichi chigadzirwa (s) chinogara pane kambani ye APICMO.

Kukwanisa kubereka, kugadzira uye kugadzira zvakawanda zve 3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine (83255-86-1) nehutano hwehutsika pasi peCGMP
mitemo.

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tsananguro

3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-amine (83255-86-1) video

Nhamba ye3,4-disubstituted pyrazolo [3,4-d] pyrimidine ribonucleosides yakagadzirwa uye yakaedzwa nokuda kwebasa rayo. Glycosylation ye persilylated pamwe neyonsilylated 3-bromoallopurinol ne 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (4) iyo yakaisa mukati mechikamu 3-bromo-1- (2,3,5-tri-O-benzoyl- β-D-ribofuranosyl) pyrazolo [3,4-d] pyrimidin -4 (5H) -one (5a). Saizvozvowo glycosylations ye3-cyanoallopurinol uye 3- (methylthio) allopurinol yakapa zvinokwana zvakachengetedzwa zvinonzi N-1 glycosyl derivatives (5b uye 5c). Debenzoylation yeyi nucleosides (5a-c) yakapa 3-bromo, 3-cyano-, uye 3- (methylthio) allopurinol nucleosides (6a-c). Nzvimbo ye glycosylation uye anomeric configuration ye 6a ne6c dzakagoverwa maererano neshanduro dzepirat uye pamwe nekushandura ku allopurinol ribonucleoside, asi basa rakagadzirirwa re 6b rakaitwa ne-single-crystal X-ray kuongorora. Kushandurwa kweboka rinoshandiswa kweboka re5a uye 5b rakapa nhamba yakaverengeka yeA3-yakashandurwa allopurinol nucleosides, iyo yaisanganisira 18a-d. Glycosylation ya 4-amino-3-bromopyrazolo [3,4-d] pyrimidine ne4 uye debenzoylation yakatevera yakapa 3-bromo-4-aminopyrazolo [3,4-d] pyrimidine ribonucleoside iyo 3,4-dino-β-D-ribofuranosylpyrazolo [3,4-d ] pyrimidine yakagadzirwa nokumutsa. Kutorwa kwe5b, kwakateverwa nokudengenyeka, kwakapa 3-cyanothiopurinol ribonucleoside (20). Zvose izvi zvinowanzoedzwa mu vitro maererano nemamwe mavharusi, tumoramu masero, uye maruva anonzi Leishmania tropica. Pakati pe3-yakashandurwa allopurinol nucleosides, 18b uye 18c vakaratidza chiitiko chakakonzera kupararira kwePara 3 uye vakawanikwa kuti vane simba rekudzivirira kweL1210 neP388 leukemia. Chigadzirwa 20 chakaratidza chinonyanya kukosha mumashiripiti emishonga antiviral uye antitumor. 3-Bromoallopurinol ribonucleoside (6a) yakaratidzwa kuva yakashanda kupfuura allopurinol ribonucleoside neLeishmania tropica mukati me macrophage vanhu mu vitro.

Ichi chigadzirwa (s) chinogara pane kambani ye APICMO. Kana uri kutarisa peji ino somunhu asina kubhadhara, mutengo (s) unoratidzirwa ndiNhamba yeZveruzhinji. Kuti uone kutengesa kwako, pinda mukati uchishandisa nhamba yako yekodha, kana kuti iwe unyoresa waunoshandisa kuburikidza neimwe yemakambani eChipatimendi Chebasa. Kuti uise mutemo, taura APICMO Customer Service.

3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-amine (83255-86-1) Specifications

CAS 83255-86-1
CAS Min% 97%
CAS Max% 100%
MDL Nhamba MFCD12196922
InChI Key GZQVGSRUUTUJNG-UHFFFAOYSA-N
Kemikari Zita kana Nyaya 3-Bromo-1h-pyrazolo [3,4-d] pyrimidin-4-amine
Infrared Spectrum zvechokwadi
Physical Form Powder kana Chunks
Packaging Bhodhoro regirazi
Molecular Formula C5H4BrN5
Molecular Weight (g / mol) 214.026
SMILES C1 = NC2 = NNC (= C2C (= N1) N) Br
ruvara
Melting Point 350 ° C (lit.)
Assay 97% ~ 100%

3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine (83255-86-1) Kuchengeta nekubata

(83255-86-1) Tsanangudzo yenjodzi:

• Zvinokonzera kutsamwa kweganda

• Zvinokonzera kushungurudzika kweziso.

3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine Kuchengetedza zvinyorwa:

♦ Kushambidza maoko uye chiso chakanaka mushure mokubata.

• Shfeka magasi ekudzivirira, kudzivirira kweziso

♦ Kana iri paganda: Shamba nesipo yakawanda nemvura. Kana kushungurudzwa kweganda kunoitika: Tsvaga mazano ekurapa kana kutarisirwa. Bvisa zvipfeko zvakasvibiswa uye uzvishambidze usati washandisazve.

♦ Kana ari maziso: Isai zvakanaka nemvura kwemaminitsi akawanda. Bvisa manotsi lenzi, kana zviripo uye zviri nyore kuita. Rambai muchigadzira. Kana kushungurudzwa kweziso kuchiripo: Tsvaga mazano ekurapa kana kutarisirwa.

YAMBIRO: Mashoko aya anowanikwa pane iyi webhupu yakagadziridzwa maererano nemitemo yeEuropean Union (EU) uye yakarurama kune zvakanakisisa zvezivo yedu, ruzivo uye rutendo pazuva rawakabudiswa. Mashoko anopiwa anogadzirirwa chete semutungamiri wekusachengetedza nekuchengetedza zvakachengeteka. Izvo hazvifaniri kuonekwa sechirango kana kuti maitiro ehutano.

3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-amine (83255-86-1) Articles

Bromopyrazolo [3,4-d] pyrimidine 2'-deoxy-2'-fluoro-β-D-arabinonucleosides: Modified DNA yakaitwa neshuga yakasimba zvakanyanya N-conformation

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Synthesis, anticancer evaluation, uye masvomomu ekuongorora zvinyorwa zveimwe nhoroondo 4,6-disubstituted pyrazolo [3,4-d] pyrimidines se cyclin-dependent kinase 2 (CDK2) inhibitors

Bioorganic Chemistry 2018

Technical Service:

Bato revasayendisiti vane ruzivo munharaunda dzose dzekutsvakurudza kusanganisira Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical nezvimwe zvizhinji.

3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine (83255-86-1) Kurayira Kuwanda uye Mutengo:

Iwe unoda huwandu hwakawandisa nokuda kwekutsvaga kwako, kushandiswa kana kutsvakurudza zvese?


=

1 Kudzokorora nokuti 3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-amine (83255-86-1)

  1. APICMO -

    Pa APICMO, tinogadzira uye tinobudisa yakawanda ye3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine, pakati pemamwe makemikari. Zvitengesi zvedu zvinoteerera mitemo ye federal uye CGMP mitemo yekutengesa.

    Ichi chikemikari chinowira pasi pezvikamu zveheterocycles, nucleosides, pyrimidines, pyridines, uye zvivakwa zvavo zvakafanana. Inobatsira pakutsvakurudza, kubudirira, kana kubudisa.

    Product specifications

    Kemikari zita 3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine
    IUPAC zita 3-Bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine
    CAS inokosha Min% - 97

    Max% - 100

    CAS no. 83255-86-1
    Synonyms · 3-Bromo-1H-pyrazolo [3,4-d] pyrimidin-4-amine
    · 1H-pyrazolo [3,4-d] pyrimidin-4-amine, 3-bromo
    · 3-bromo-4-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidine
    · 3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine
    · 7-bromo-2,4,8,9-tetrazabicyclo[4.3.0]nona-2,4,6,9-tetraen-5-amine
    · 1h-pyrazolo [3,4-d] pyrimidin-4-amine
    · 3-bromo-1H-pyrazol [3,4-d] pyrimidin-4-amine
    · 3-bromopyrazolo [5,4-d] pyrimidine-4-ylamine
    Molecular weight (g / mol) 214.0228
    Molecular formula C5H4BrN5
    Muviri wehumu (g / mol) 214.023
    Monoisotopic mass (g / mol) 212.965
    Structural formula 3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-amine (83255-86-1)
    Chimiro chemuviri Zvinyorwa zvakasimba kana poda
    Ikemikari yakachena 97%
    Kuwanda kwevanhu (g / cm3) 2.14
    Pfungwa inoputika (˚C) 350 ° C
    Packaging Bhodhoro regirazi

    Kemikari uye Zvimwe Zvisikwa zve3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine

    1. Kushamwaridzana
    Hydrogen bond Acceptor count - 5 units

    Mupiro wezvipo - 3 diyuniti

    Rotatable bond 0
    Covalent 1 unit
    1. Kuonekwa

    3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine inowanika mufomu yeupfu kana yakasimba chunk.

    1. Kunzwisisa

    Chigadzirwa chacho chinonzwisa chiedza, kupisa, uye unyoro. Kana ichitaura kune chero ipi zvayo mamiriro aya, 3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-inogona kuora.

    Computed Properties

    Name Name Property value
    Misa chaiye (g / mol) 212.965
    Complexity 154
    Topological polar surface area 80.5 A ^ 2
    Isotope Atom Count 0
    Kunotsanangurwa Bond Stereocenter Count 0
    Kunotsanangurwa Atom Stereocenter Count 0
    Usingazivikanwi Atom Stereocenter Count 0
    Kusagadziriswa Bond Stereocenter Count 0
    Mutemo Wakafanana 0
    Heavy Atom Count 11
    XLogP3-AA 0.8
    Compound Is Canonicalized Ehe
    Refractive index 1.851
    Molar volume (cm3) 100
    Molar refractivity (cm3) 44
    Surface mhirizhonga (dyne / cm) 117.8
    Kunyanya kukwana (g / ml) 2.14

    Zvishandiso zve3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine

    APICMO hazard icons

    • Mishonga yemishonga yakadai sekudziviswa kweSrc kinases
    • Chigadzirwa chekutsvakurudza nekuvandudza
    • Synthesis yemamwe makemikari

    Njodzi dzinobatanidza Nekushaya Masimba kwe3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine

    3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine inogona kuva nengozi kumutano wevanhu. Nokudaro, inofanira kutarisirwa nemutsvakurudzi ane ruzivo kana pasi pekutariswa kwepedyo kweyanyanzvi. Heano mamwe ematambudziko ekushandura chigadzirwa chacho:

    • Zvinokonzera mishonga yeganda kana yakanyatsobatana nemuviri
    • Ziso rakanyanya kutsamwa kana kukanganisa zvachose
    • Zvinokuvadza kumutsipa wekupumha kana ukabatanidzwa
    • Inotyisa kana ikamedza

    Zvokuchengetedza Zvingaitika Kana uchibata ne 3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine

    1. Panguva Yokubata Chimiro

    Paunenge uchishanda na3-Bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine, cherechedza zvinotevera:

    • Shanda mune imwe nzvimbo yakanyatsokonzerwa nemhepo
    • Pfekai zvipfeko zvekudzivirira kuti ufukidze muviri wako wose kusanganisira maoko, tsoka, ganda, uye chiso kuti usasangana nechinangwa
    • Usadya, kuravira, kana kunwa chero chinhu pane laboratori
    • Shandisa kemikari fume chamber

    2. Mushure mekushandisa

    Mushure mokushanda tsvakurudzo dzenyu, kubudirira kana chigadzirwa, funga zvinotevera:

    • Chengetedza kemikemikari yakasara mumudziyo wakavharwa zvakasimba
    • Inzvimbo yekuchengetedza inofanira kuva yakanaka uye yakaoma
    • Dzingai chigadziko kana kuti mugumo wezvigadzirwa maererano nehurumende kana yepamutemo mitemo inotungamirira kuparadzwa kwemarara
    • Geza maoko ako uye chiso chako nemvura yakakwana
    • Bvisa pane nguo dzakasvibiswa usati watorazve
    • Geza uye gadzirisa bhenji rekushanda

    3. Kana isiri muKushandiswa

    Kana usingabatsiri, cherechedza zvinodzivirira pasi apa:

    • Chengetera pasi pemhepo yakadzika yakadzika, zvichida mufiriji
    • Chengetedza ichivharirwa mumudziyo wakavharwa zvakasimba

    4. Zvimwe Zvokudzivirira Zvokushandisa

    Nguva dzose uchengetedze muviri wakakwana kudzivirira kuderedza ngozi dzinogona kuitika kana ngozi.

    • Kuchengetedzwa kweziso

    Isai magirazi ekuchengeteka kuti murege kudzivirira 3-Bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine kana zvayo-michina yekupinda mumeso uye kukonzera kutsamwa.

    • Kuchengetedzwa kweganda

    Kupfekedza sutu yakazara kuti ufukidze chikamu chakapfeka chenyama.Puti pamabhuruku kana musina kupfeka uye makemikari asingadziviriki.

    • Dzorera kudzivirirwa

    Kupfekedza zvakakodzera chiso chemasikisi nemhepo-kuchenesa zvigadziro kubudisa guruva, mhute, mafungu, kana chimwe chinhu.

    • Kudzivirira kupora

    Kuti udzivirire kuputika kwemhepo inokuvadza, iyo inogona kuvhiringidza nzira yekufema, funga kuisa mupiritsi neHEPA filters.

    5. Kutanga Kubatsira Maitiro

    Izvi zvinotarisirwa kunetseka zvinofanira kupiwa pakarepo mushure mokunge zvikaitika. Zvisinei, havatombotori nzvimbo yekutarisira kurapwa. Kana zviratidzo zvichiripo, funga nezvekushanyira chiremba.

    Kuti upe rubatsiro rwekutanga pane nguva, laboratori yako inofanira kuve yakagadzirirwa nekuchengetedzwa kwekuchengetedza, kemikemikari yomukati, kupedza kuputika kwemazamu, uye kushamba kweziso.

    • Taura neganda

    Shenesa nzvimbo yakagadziriswa nemvura yakawanda ine mvura uye sophorera zvishoma pamusoro pemaminitsi e10. Mvura inofanira kunge inotonhora. Kana kutsamwa kana kuora kunopfuurira, tsvaka mazano emishonga.

    • Inhalation

    Enda kune imwe kamuri rine hewa yakakwana kana nzvimbo yakazaruka ine simba guru rekupa. Kana munhu akabatwa nematambudziko mukufema, anoisa mumhepo yakasati vasati vatsvaga kurapwa.

    • Kuisa

    Shamba muromo zvakakwana nemvura yakakwana yechando kwemaminitsi anoverengeka. Iwe unogonawo kunwa mvura yakawanda. Kana zviratidzo zvichiripo, tsvaka mazano kubva kumishonga.

    • Eye contact

    Kana iwe uine majekiti ekubvisa, usabvisa vasati vashamba maziso nemvura yakakwana kune maminitsi 10.

    6. Kuchengetedza nekubata

    • kukurukurwa

    3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine inofanira kushandiswa nenyanzvi inoziva nezvezvipingamupinyi zvinosanganiswa uye kuti vanogona sei kuzvidzivirira. Nguva dzose ufuke zvakagadzikana zvemuviri zvakakodzera maererano nehutano hwehutano hwehutano uye ushande mune imwe nzvimbo ine nzvimbo yakakwana yekudzivirira.

    Dzivisa kuvhiringidza guruva kana mhepo yakabudiswa nemakemikari. Chimwe chezvinhu zvinopisa zvinokonzerwa ne3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amineare hydrogen bromide uye bromine, iyo inotyisa kana inoputika. Mhepo inopisa zvose maziso uye nzira yekufema.

    • chengetedzo

    Chengetedza 3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine isimbi yakavharwa zvakasimba uye inoivhara munzvimbo yakachengeteka nepamhepo yakawanda. Ichengetedze kunze kwekusvika kwevashandi vasingabvumirwi.

    7. Kuramba uye Kubudirira

    3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine inonzwisisa chiedza, kupisa, uye unyoro.

    8. Kupisa moto kunodzora

    Kana icho chigadzirwa kana chipiri chemikemikari ichikonzera moto, bvisa murazvo uchishandisa kabhoni dioxide, doro, yakaoma yehuta kana polymer mutezo. Shandisa zvipfeko zvinodzivirira panguva yekushisa moto. Pasi pane mamwe emiti inopisa ye3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine:

    • Hydrogen bromide
    • Bromine
    • kabhoni
    • Carbon monoxide
    • Carbon dioxide
    • Nitrogen
    • Oxides ye nitrogen

    9. Spillages

    Kana uri muhutano hwakasimba, nyora zvinyorwa uye udzire zvakakodzera. Paunenge uri mumvura yakachena, usarega ichiyerera pasi pemvura kana imwe nzira. Bvisai tsvina nemafuta anogadzirisa, bvisai mudziyo maererano nemirairo yekurasa, geza bhenji rekushanda, uye ventilate iyo.

    10. Kurasikirwa Kwemakemikari

    Dzinga 3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine maererano nemunharaunda, mamiriro ehurumende, kana hurumende, inoshandisa nzira yemakemikari yakasara.

    11. Kutumira mashoko

    Hapana hutano hunozivikanwa hwekutakura 3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine kana pasi kana mhepo.

    Information Regulatory Information

    3-bromo-2H-pyrazolo [3,4-d] pyrimidin-4-amine inopindirana nemitemo yehurumende uye yezvematongerwo enyika inodzora chikombiyamu chikamu, uye haipfuuri nepamusoro yepamusoro yeCAS reporting level maererano neSARA musoro III mitemo.

    Bibliographie

    1. National Centre For Biotechnology Information, US. National Library Of Medicine, Pubchem, 3-Bromo-2H-Pyrazolo [3,4-D] Pyrimidin-4-Amine, Zvikamu 1-10.
    2. Volkan Kisakürek, M. Volkan Kisakürek, Maonero muNucleoside uye Nucleic Acid Chemistry, peji 1-5
    3. Office of Toxic Substances, United States. Environmental Protection Agency. Office of Pollution Prevention and Toxics - 1995, peji 56
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