4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9)

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Kukwanisa kubudisa, kugadzira uye kugadzira zvakawanda zve 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9) nehutano hwehutsika pasi peCGMP
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4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) video

Janus kinases (JAKs) inotora basa rinokosha mukushandurwa kwechiratidzo chinonzi medito. JAK inhibitors yakabuda semagadzirirwo emakonomodulative mazhenesti ekudzivirira kwekudzikwa kwekuisa. Takave takazivisa kuti tricyclic imidazo-pyrrolopyridinone 2 inonyanya kukosha JAK inhibitor; zvisinei, zvakange zvisingatauri zvakanzwika pamusana pekudzivirira membrane kukwana. Pano, tinoshuma kugadziridza kwechimiro chekombani 2 mu tricyclic dipyrrolopyridine 18a inotarisa kuderedzwa kwenzvimbo yePolar surface (PSA), iyo inoratidzira basa rakanyanya mu vitro, yakagadziridzwa membrane kugadziriswa uye zvakanaka bioavailability. Chigadzirwa 18a chakaratidza kubudirira muhutachi heterotopic mwoyo kuchinja mafomu.

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4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) Specifications

CAS 918515-16-9
CAS Min% 95%
CAS Max% 100%
MDL Nhamba MFCD09880129
InChI Key DYWWVLQMUUZZRJ-UHFFFAOYSA-N
Kemikari Zita kana Nyaya 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde
Infrared Spectrum zvechokwadi
Physical Form Muchena kusvika mavara akaoma
Packaging Bhodhoro regirazi
Molecular Formula C8H5N2OCl
Molecular Weight (g / mol) 180.594
SMILES ClC1 (= C2 (C (= NC = C1) NC = C2C = O))
ruvara Chena
Boiling Point 372.6 ° C pa 760 mmHg
Assay 98%

4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9) Kuchengetedza uye Kugadzirisa

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  • Chengetedza munzvimbo yakachena, yakaoma, ine zvakanaka.
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4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) Articles

Kuwana tricyclic dipyrrolopyridine zvigadzirwa semutsva JAK inhibitors

Janus kinases (JAKs) inotora basa rinokosha mukushandurwa kwechiratidzo chinonzi medito. JAK inhibitors yakabuda semagadzirirwo emakonomodulative mazhenesti ekudzivirira kwekudzikwa kwekuisa.

Bioorganic uye Medicine Chemistry 2017

Synthesis uye biological test of pyrrolo [2,3-b] pyridine yakafanana sevanopesana nemaitiro uye kushamwaridzana kwavo nemhuru yemusmus DNA

Tsamba ye makumi matatu nemaviri pyrrolo inoverengeka [2,3-b] pyridine yakafanana yakagadzirwa, inozivikanwa (1H NMR, 13C NMR uye MS) uye yerototoxic kuongororwa kwemaserolekisi akaitwa pamusoro peboka revanhu vatatu chemasero emasero evanhu anosanganisira A549

European Journal of Medicinal Chemistry 2016

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4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9) Kurayira Kuwanda uye Mutengo:

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