4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9)

(2 kasitoma wongororo)

Ichi chigadzirwa (s) chinogara pane kambani ye APICMO.

Kukwanisa kubudisa, kugadzira uye kugadzira zvakawanda zve 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9) nehutano hwehutsika pasi peCGMP
mitemo.

Category:

tsananguro

4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) video

Janus kinases (JAKs) inotora basa rinokosha mukushandurwa kwechiratidzo chinonzi medito. JAK inhibitors yakabuda semagadzirirwo emakonomodulative mazhenesti ekudzivirira kwekudzikwa kwekuisa. Takave takazivisa kuti tricyclic imidazo-pyrrolopyridinone 2 inonyanya kukosha JAK inhibitor; zvisinei, zvakange zvisingatauri zvakanzwika pamusana pekudzivirira membrane kukwana. Pano, tinoshuma kugadziridza kwechimiro chekombani 2 mu tricyclic dipyrrolopyridine 18a inotarisa kuderedzwa kwenzvimbo yePolar surface (PSA), iyo inoratidzira basa rakanyanya mu vitro, yakagadziridzwa membrane kugadziriswa uye zvakanaka bioavailability. Chigadzirwa 18a chakaratidza kubudirira muhutachi heterotopic mwoyo kuchinja mafomu.

Ichi chigadzirwa (s) chinogara pane kambani ye APICMO. Kana uri kutarisa peji ino somunhu asina kubhadhara, mutengo (s) unoratidzirwa ndiNhamba yeZveruzhinji. Kuti uone kutengesa kwako, pinda mukati uchishandisa nhamba yako yekodha, kana kuti iwe unyoresa waunoshandisa kuburikidza neimwe yemakambani eChipatimendi Chebasa. Kuti uise mutemo, taura ne APICMO Customer Service.

4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) Specifications

CAS 918515-16-9
CAS Min% 95%
CAS Max% 100%
MDL Nhamba MFCD09880129
InChI Key DYWWVLQMUUZZRJ-UHFFFAOYSA-N
Kemikari Zita kana Nyaya 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde
Infrared Spectrum zvechokwadi
Physical Form Muchena kusvika mavara akaoma
Packaging Bhodhoro regirazi
Molecular Formula C8H5N2OCl
Molecular Weight (g / mol) 180.594
SMILES ClC1 (= C2 (C (= NC = C1) NC = C2C = O))
ruvara Chena
Boiling Point 372.6 ° C pa 760 mmHg
Assay 98%

4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9) Kuchengetedza uye Kugadzirisa

  • Usafema guruva kana kupisa.
  • Iva nekuchengeteka kushambidza uye kushambidza kweziso kuwanikwa.
  • Usasvike mumaziso, paganda kana panguvo.
  • Chengetedza chigadziko chakanyatsovharwa.
  • Chengetedza munzvimbo yakachena, yakaoma, ine zvakanaka.
  • Iva nechokwadi chekuti mudzimu wakakwana unoshandiswa.
  • Shandisa chete mumakemikari fume hood.

YAMBIRO: Mashoko aya anowanikwa pane iyi webhupu yakagadziridzwa maererano nemitemo yeEuropean Union (EU) uye yakarurama kune zvakanakisisa zvezivo yedu, ruzivo uye rutendo pazuva rawakabudiswa. Mashoko anopiwa anogadzirirwa chete semutungamiri wekusachengetedza nekuchengetedza zvakachengeteka. Izvo hazvifaniri kuonekwa sechirango kana kuti maitiro ehutano.

4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) Articles

Kuwana tricyclic dipyrrolopyridine zvigadzirwa semutsva JAK inhibitors

Janus kinases (JAKs) inotora basa rinokosha mukushandurwa kwechiratidzo chinonzi medito. JAK inhibitors yakabuda semagadzirirwo emakonomodulative mazhenesti ekudzivirira kwekudzikwa kwekuisa.

Bioorganic uye Medicine Chemistry 2017

Synthesis uye biological test of pyrrolo [2,3-b] pyridine yakafanana sevanopesana nemaitiro uye kushamwaridzana kwavo nemhuru yemusmus DNA

Tsamba ye makumi matatu nemaviri pyrrolo inoverengeka [2,3-b] pyridine yakafanana yakagadzirwa, inozivikanwa (1H NMR, 13C NMR uye MS) uye yerototoxic kuongororwa kwemaserolekisi akaitwa pamusoro peboka revanhu vatatu chemasero emasero evanhu anosanganisira A549

European Journal of Medicinal Chemistry 2016

Technical Service:

Bato revasayendisiti vane ruzivo munharaunda dzose dzekutsvakurudza kusanganisira Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical nezvimwe zvizhinji.

4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9) Kurayira Kuwanda uye Mutengo:

Iwe unoda huwandu hwakawandisa nokuda kwekutsvaga kwako, kushandiswa kana kutsvakurudza zvese?


=

2 anodzokorora nokuti 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9)

  1. APICMO -

    Pa APICMO, tinogadzira uye tinogadzira zvakawanda zve4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde, pakati pemamwe makemikari. Zvigadzirwa zvedu zvinoenderana neCGMP yekugadzira mitemo uye inonyanya kutsvakurudza, kubudirira, nekugadzirwa.

    4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde Description

    JAKs kana Janus kinases dzinobatsira kuendesa kwechiratidzo chemugodhikine. Kutsvakurudza kwakatsigira JAK inhibitors kuti ive immunodulative agents, izvo zvinonyatsodzivirira kuiswa kwechimiro chemuviri. Pakutanga, tricyclic imidazo-pyrrolopyridine2 yaiva yedu yepamusoro JAK inhibitor kusvikira tawana iyo ine membrane yakadzika inokwana iyo inowedzera kukanganisa mumuromo.

    Kugadziriswa kwemugadziri pane tricyclic imidazo-pyrrolopyridine 2 inoderedza nzvimbo yepurasitiki, zvichidaro, zvichiita kuti tricyclic imidazo-dipyrrolopyridine iwedzere. Ichi chikamu chine unhu hunovandudzika nehuwandu hwakanaka hwekunyorera mumuromo, uye hunoisa maitiro ane simba e vitro. Apo yaitungamirirwa mumakirini epfungwa yokutengesa mwoyo, yaive yakakosha.

    (918515-16-9) Product Specifications

    Synonyms · 4-Chloro-7-azaindole-3-carbaldehyde

    · 4-Chloro-3-formyl-7-azaindole

    Structural formula 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde(918515-16-9)
    Purity 98% yakachena
    Chimiro chemuviri simba
    Monoisotopic mass (g / mol) 180.009
    Molecular weight (g / mol) 180.591
    Molecular formula C8H5ClN2O
    Flash point (˚C) 179.1
    Kuwanda kwevanhu (g / cm3) 1.521
    Kemikari zita 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde
    CAS no. 918515-16-9
    Boiling Point (˚C) 372.6 pa 760 mmHg

    4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde

    Makemikari uye Zvimwe Zvisikwa o

    Kuramba

    4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde yakawanda pasi pemamiriro ezvinhu akadai. Zvisinei, rega kugadziriswa kwechigadzirwa kune zvakanyanya kutonhorera, unyoro, kana simba rakasimba yeiri oxidzinge sezvo zvingaita kuti kugadziriswa.

    4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde Kushamwaridzana

    Hydrogen bond Mupiro wezvipo - 1 unit

    Kugamuchira kuverenga - 2 diyuniti

    Covalent
    Rotatable bond 1

    Kuonekwa

    4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde isimbi yakachena-tsvuku.

    4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9): Computed Properties

    Name Name Property value
    Complexity 188
    Compound is Canonicalized Ehe
    Kunotsanangurwa Atom Stereocenter Count 0
    Kunotsanangurwa Bond Stereocenter Count 0
    Enthalpy ye vaporization (kJ / mol) 61.97
    Misa chaiye (g / mol) 180.009
    Mutemo Wakafanana 0
    Heavy Atom Count 12
    Isotope Atom Count 0
    Polar surface area (PSA) 45.75 Å2
    Refractive index 1.748
    Surface mhirizhonga (dyne / cm) 71.9
    Topological polar surface area 45.8 A ^ 2
    Usingazivikanwi Atom Stereocenter Count 0
    Kusagadziriswa Bond Stereocenter Count 0
    Vapor pressure (mmHg) 9.53E-6
    XLogP3-AA 1.4

    Synthesis Route ya 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde

    Pasi pane nzira mbiri dzekugadzira chigadzirwa:

    Tetrahydro-4-pyranol (2081-44-9)

    4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9): Uses

    Chibereko chacho chinonzi mishonga inoshandiswa nemishonga, iyo inoshanda seJAK inhibitor yekudzivirira chimiro chekugadzirisa kubviswa

    Njodzi Dzinosangana ne4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde

    • Zvinokuvadza kana zvinyungudzwa uye zvinogona kutungamirira kumhepo yekutsamwa, kupera kwekufema, kana kushungurudzika
    • Zvinokonzera kuora, kubwinya, kana kuora kweganda panguva yakabatana
    • Inonyangadza kana ikamedza, inotungamirira kuhutu hunopisa
    • Kushungurudzwa kweziso kana kuparara zvachose

    Kuchengetedzwa kunobata pakubata 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde

    1. Kudzivirirwa Kwemunhu

    Kupfekedza masikisi nemhepo yekuchenesa mhepo kunodzivirira kushaya mungozi, izvo zvingave zvichitsamwisa nzira yekufema.Kuisa maoko ako netsoka dzako, pfeka magirazi asingadziviriri magasi nemabhoti asina kuvhara, maererano. Kupfekedza sutu yakakwana yemuviri yekuvhara nekudzivirira ganda.

    2. (918515-16-9): Engineering Controls

    Iva nechokwadi chokuti nzvimbo yako yekushanda yakagadzirirwa hove inopisa, mashizha, mafoni ekuchenesa mweya, kuchengetedzwa kwemhepo, eyewash, uye makabati.

    3. Kutanga Kubatsira Maitiro

    • Inhalation

    Sungedza muromo pamusoro pemaminitsi e10. Inwa mvura yakawandisa inenge hafu yefa. Kana zviratidzo zvinoramba zvichiripo, taura nesheji kana kutsvaga kurapwa.

    • Kubatana kweganda

    Bvisa chero zvipfeko zvakasvibiswa pakarepo. Shamba nzvimbo yakagadziriswa nemvura yakakwana yemvura kune anenge 15 maminitsi. Tsvaka rubatsiro rwemishonga kana zviratidzo zvichiripo.

    • Inhalation

    Endesa uyo akabatwa mukamuri rine hukuru hwemhepo kana nzvimbo yekunze. Kana zviratidzo zvikava zvakanyanya sekukanganisa kufema, shandisa oxygi kutsigirwa uye enda kune chiremba.

    • Eye contact

    Bvisa manotsi emaferensi kana iwe uine ivo. Kurisa maziso ane mvura yakawandisa yemaminetsi e10 anotevera.

    4. Paunoshandisa 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde

    Kana chigadzirwa chacho chiri kushandiswa, funga nezvemashoko pasi apa:

    • Shandisa iyo mufume hood
    • Pfekai magadziro ekudzivirira maererano nehutano uye hurumende yemitemo yekuchengeteka
    • Shanda mune imwe imba uye uine ventiroti yakawanda

    5. Mushure mekushandisa

    Mushure mekushandisa 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde, heano zvimwe zviyero zvekutora:

    • Chengetedza maikemikari akasara pasi pekudziya kwepasi
    • Dzinga zvimedu zvisina chinhu uye zvigunwe zvakakodzera
    • Shamba zvachose maoko ako
    • Bvisa nguo dzakasvibiswa uye uzvishambidze usati washandisazve

    6. Apo kunze kweKushandiswa

    Kana isiri kushandiswa,

    • Chengetedza makemikisi mune chisimbiso chakasimba kuti urege kukwanisa kuwana
    • Chengeta iyo firiji
    • Dzivisa kuisa pachena kune kupisa kana mamwe makemikari

    7. 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde Kuchengetedza nekubata

    chengetedzo

    • Chengetai iyo firiji, zvichida pa -20˚C
    • Chengetedza mumatanda akavharwa zvakasimba
    • Zviise munzvimbo inotonhorera uye yakaoma
    • Chengetedza chemikemikisi mumakabati ekuvhara kuti usabvumirwe kupinda mvumo

    kukurukurwa

    • Pfekai zvishandiso zvemunhu
    • Shandisa mune imwe makemikari fume hood
    • Shanda mune imwe nzvimbo yekunze kana kamuri yakanaka
    • Usapinza chero moto, gasi, guruva, kana zvimwe zvinokonzera

    8. Fire Control

    Pfekai zvipfeko zvekudzivirira nekufema mafungiro. Kuchenesa murazvo nemapenzi, carbon dioxide, kana kuti makemikari akaoma. Zvinhu zvinopisa zvinokonzerwa ne4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde zvinosanganisira oxyx ye nitrogen, HCl, uye carbon monoxide.

    9. Kutarisira Kurapa

    Paunenge uri mumvura yakasviba, funganisa nayo nezvinhu zvakanyanyisa kuvhara, kuchenesa, uye kurasa mubhodhi rakanyorwa uye rakavharwa. Nokuda kwehutano hwakasimba, shandisai makemikari uye ezvigadzire zvakakodzera. Usambobvumira kuparadzaniswa kuwana nzira yavo kuburikidza nemigero yemvura kana mvura.

    10. Kemikari Stability uye Reactivity

    11. Kurasikirwa Kwemakemikari

    Shandisa 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde sechinhu chakasvibiswa uye inorasirwa maererano nemitemo yemunharaunda yemunharaunda. Paunoshandisa mazano ekambani yemunharaunda, ona kuti yakanyoreswa uye inobvumirwa.

    12. 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9): Kutumira Info

    Hakuchina njodzi dzinozivikanwa nemhepo kana kutakurwa kwepasi kwe4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde.

    Regulatory Info

    Kuvhara uye chikumbaridzo che4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde inopindirana nehuwandu hunokosha hwakataurwa neSARA Chikamu III zvikamu 302 uye 313.

    4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde

    Tsvakurudzo dzedu dzesayenzi dzine ruzivo rwakanyanya mune zvenyama nehupenyu sciences, makemikari ekuongorora, synthesis, uye chromatography.

    4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9): Kurongedza Kukuru uye Mutengo

    Kana iwe uchida 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde yakawanda, nokuda kwekutsvakurudza kwako uye kubudirira, ita kuti iwe urongedze nesu kuburikidza nekutaura kwebasa rekuchengetedza vatengi.

    Bibliographie

    1. National Centre For Biotechnology Information, US. National Library Of Medicine, Pubchem4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde, Zvikamu 1-10
    2. Naoki Katsuki, Shumpei Isshiki, Juan Okamura, Kouji Kuramochi,, and Kazunori Tsubaki Journal of Organic Chemistry2017 82 (21), 11563-11572
    3. Ihle JN, Thierfelder W, Teglund S, et al. Chiratidzo ne cytokine receptor superfamily. Ann NY Academy Sci. 1998; 865: 1-9

  2. Apicmo -

    Yakanakisisa 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde nebasa randakave narina, Nice experience

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