Tetrahydro-4-pyranol (2081-44-9)

(2 kasitoma wongororo)

Ichi chigadzirwa (s) chinogara pane kambani ye APICMO.

Kukwanisa kubudisa, kugadzira uye kugadzira zvakawanda zveTetrahydro-4-pyranol (2081-44-9) nehutano hwehutsika pasi peCGMP
mitemo.

Category:

tsananguro

Tetrahydro-4-pyranol (2081-44-9) video

(Ikemikari Equation Yakaratidzwa). Mumakore achangobva kupfuura, chizvarwa chekutanga che β-secretase (BACE1) inhibitors chakatangira mukurapa kwechirongwa chekurapwa kweAlzheimer's disease (AD). Zvisinei, kuenzaniswa kwezvinodhaka-semasimba uye sarudzo inoramba iri dambudziko guru. Pano, tinotsanangura kuwanikwa kwekirasi inoverengeka yepamusoro, yakaderera pasi, CNS inopindira BACE1 inhibitors inomiririrwa ne thioamidine 5. Kuwedzera kufungidzira kwakaratidza kuti chikamu chakakura chemasabolism (> 95percent) chakanga chakaitwa neCYP2D6, kuwedzera njodzi inogona kuitika kune vanobatwa-zvinokonzerwa nezvinodhaka-zvinodhaka (DDI) uye kushandiswa kwakafanana mumakirini nekuda kwepolymorphic iyo ye enzyme iyi. Kuti inotungamira ramangwana rakagadziriswa, yakagadziriswa kristani dzimba dzeCYP2D6 complexes ne substrate 5 uye inogadzirwa nemishonga yemagetsi pyrazole 6, iyo yakapa ruzivo pamusoro pemagadzirirwo ekutenderera nekufamba pakati pe substrate / inhibitor complexes. Kutungamirirwa neBACCE1 neYYP2D6 kristal structures, yakagadzirirwa uye yakagadzirwa zvakafanana nehuwandu huripo hweDDI, hunobudirira hwehutano, uye huri nani huri mishonga yekurapa.

Ichi chigadzirwa (s) chinogara pane kambani ye APICMO. Kana uri kutarisa peji ino somunhu asina kubhadhara, mutengo (s) unoratidzirwa ndiNhamba yeZveruzhinji. Kuti uone kutengesa kwako, pinda mukati uchishandisa nhamba yako yekodha, kana kuti iwe unyoresa waunoshandisa kuburikidza neimwe yemakambani eChipatimendi Chebasa. Kuti uise mutemo, taura ne APICMO Customer Service.

Tetrahydro-4-pyranol (2081-44-9) Tsanangudzo

CAS 2081-44-9
CAS Min% 95%
CAS Max% 100%
MDL Nhamba MFCD00006633
InChI Key LMYJGUNNJIDROI-UHFFFAOYSA-N
Kemikari Zita kana Nyaya Tetrahydro-4-pyranol
Infrared Spectrum zvechokwadi
Physical Form Bvisa Liquid pa 20 ° C
Packaging Bhodhoro regirazi
Molecular Formula C5H10O2
Molecular Weight (g / mol) 102.133
SMILES C1COCCC1O
ruvara Haina mavara-Anenge asina kuchena pa 20 ° C
Boiling Point 190 ° C
Assay 98%

APICMO hazard icons

Tetrahydro-4-pyranol (2081-44-9) Kudzivirira uye Kutarisa

  • Usafema guruva kana kupisa.
  • Iva nekuchengeteka kushambidza uye kushambidza kweziso kuwanikwa.
  • Usasvike mumaziso, paganda kana panguvo.
  • Chengetedza chigadziko chakanyatsovharwa.
  • Chengetedza munzvimbo yakachena, yakaoma, ine zvakanaka.
  • Iva nechokwadi chekuti mudzimu wakakwana unoshandiswa.
  • Shandisa chete mumakemikari fume hood.

YAMBIRO: Mashoko aya anowanikwa pane iyi webhupu yakagadziridzwa maererano nemitemo yeEuropean Union (EU) uye yakarurama kune zvakanakisisa zvezivo yedu, ruzivo uye rutendo pazuva rawakabudiswa. Mashoko anopiwa anogadzirirwa chete semutungamiri wekusachengetedza nekuchengetedza zvakachengeteka. Izvo hazvifaniri kuonekwa sechirango kana kuti maitiro ehutano.

Tetrahydro-4-pyranol (2081-44-9) Nyaya

Kushandisa Zvivako zveYPPNUMXD2 uye BACE6 Mazano ekuderedza Dambudziko reMishonga-Zvinodhaka Zvinodhaka neNorod Series Series Efficacious BACE1 Inhibitors

(Ikemikari Equation Yakaratidzwa). Mumakore achangobva kupfuura, chizvarwa chekutanga che β-secretase (BACE1) inhibitors chakatangira mukurapa kwechirongwa chekurapwa kweAlzheimer's disease (AD).

Nyaya yeMishonga Chemhemikari 2015

An atom inobudirira, isina-free-free, yakasvibirira uye antimycobacterial kuongorora kwe2-amino-6-methyl-4-aryl-8 - [(E) -arylmethylidene] -5,6,7,8-tetrahydro-4H-pyrano [3,2-c] pyridine- 3-carbonitriles

An atom inobudirira, yakasvibirira inotenderera yehuwandu hwegumi nemashanu 2-amino-6-methyl-4-aryl-8 - [(E) -arylmethylidene] -5,6,7,8-tetrahydro-4H-pyrano [3,2-c] pyridine-3-carbonitriles

Mishonga Chemistry Tsamba 2007

Technical Service:

Bato revasayendisiti vane ruzivo munharaunda dzose dzekutsvakurudza kusanganisira Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical nezvimwe zvizhinji.

Tetrahydro-4-pyranol (2081-44-9) Kurayira Kuwanda & Kutengo:

Iwe unoda huwandu hwakawandisa nokuda kwekutsvaga kwako, kushandiswa kana kutsvakurudza zvese?


=

2 anodzokorora nokuti Tetrahydro-4-pyranol (2081-44-9)

  1. APICMO -

    Pa APICMO, tinogadzira nekugadzira yakawanda yeTetrahydro-4-pyranol maererano neCGMP yekutengesa mitemo. Ichi chigadzirwa chinowira muchikamu chimwechete se heterocycles, pyrans, uye zvakakonzerwa nedzimba dzekuvaka.

    Tetrahydro-4-pyranol (2081-44-9) Tsanangudzo

    Kuwanikwa kwe β-secretase kana BACE1 inhibitors kwakaita basa rinokosha pakuchengetwa uye kurapwa kwechirwere cheAlzheimer. Dambudziko roga roga nerarudzo iyi ndeyokuti inowedzera dambudziko rekubatana kwezvinodhaka-zvinodhaka. Ongororo yakawedzera yakaratidza kuti CYP2D6 inotarisira pamusoro pe95% yemasabolism.

    Mukuda kwekugadzira inhibitor inobudirira ye β-secretase, makirasiki e-BACE1 neYYP2D6 anoongororwa. Idzi mbiri dzinobatanirana pamwe chete nemiti yakakodzana, iyo pyrazole 6. Iyo yakagadzirwa inotungamirira kune inhibitor ine ngozi shoma yekubatana kwezvinodhaka uye huri nani huri mishonga yekurapa

    (2081-44-9) Product Specifications

    Synonyms · Tetrahydro-2H-pyran-4-ol
    · Oxan-4-ol
    · 4-Hydroxy-tetrahydropyran
    · Tetrahydro-Pyran-4-ol
    · 2H-Pyran-4-ol, tetrahydro-
    · 2H-3,4,5,6-tetrahydropyran-4-ol
    · 4-hydroxy-tetrahydro-2H-pyran
    Structural formula Tetrahydro-4-pyranol (2081-44-9)
    Purity 98%
    Chimiro chemuviri Liquid pa 20 ° C
    Monoisotopic mass (g / mol) 102.068
    Molecular weight (g / mol) 102.133
    Molecular formula C5H10O2
    Chirevo Chinofanirwa Kuchengetedza (˚C) -24.06
    Flash point (˚C) 88
    IUPAC zita Oxan-4-ol
    Kuwandisa (g / mL) 1.071 pa 25 ° C
    Kemikari zita Tetrahydro-4-pyranol
    CAS no. 2081-44-9
    Boiling Point (˚C) 190

    Tetrahydro-4-pyranol: Kemikari uye Mamiriro Edzimba

    Solubility

    Tetrahydro-4-pyranol inogadzikana mumvura.

    Kushamwaridzana

    Covalent 1 unit
    Rotatable bond 0
    Hydrogen bond Mupiro - 1 unit
    Acceptors - 2 diyuniti

    Tetrahydro-4-pyranol (2081-44-9): Kuonekwa

    Tetrahydro-4-pyranol isiri isina mvura

    Tetrahydro-4-pyranol (2081-44-9) Computed Properties

    Name Name Property value
    XLogP3-AA -0.1
    Vapor pressure (mmHg) 0.23
    Kusagadziriswa Bond Stereocenter Count 0
    Usingazivikanwi Atom Stereocenter Count 0
    Topological polar surface area 29.5 A ^ 2
    Refractive index 1.462
    Polar surface area 29.46
    Isotope Atom Count 0
    Heavy Atom Count 7
    Mutemo Wakafanana 0
    Misa chaiye (g / mol) 102.068
    Enthalpy ye vaporization (kJ / mol) 48.8
    Kunotsanangurwa Bond Stereocenter Count 0
    Kunotsanangurwa Atom Stereocenter Count 0
    Compound is Canonicalized Ehe
    Complexity 48

    Synthesis Route yeTetrahydro-4-pyranol

    Iko kune zvikamu zve15 zvekutanga zveTetrahydro-4-pyranol. Pasi pane mitatu yakakwirira yekugadzira chigadzirwa, nzira yekutanga ndiyo yakakurudzirwa zvikuru:

    Tetrahydro-4-pyranol (2081-44-9)

    Tetrahydro-4-pyranol (2081-44-9) Zvishandiso

    Inobatsira muhuwandu hwekuongorora kwe3-hydroxytetrahydropyran

    Njodzi dzinobatanidza neTetrahydro-4-pyranol

    • Zvinokonzera kushungurudzika kweziso, izvo zvinogona kutungamirira kukuvadzwa zvachose
    • Inhalation inogona kukonzera kuporesa pamakumbo ekutsamwisa, kuora mwoyo, kusuruvara, kana chizuru
    • Kurwara kweganda kwakafanana nokuora, kusuruvara, uye kubhadhara
    • Dhiyabhorosi kana ikamedzwa kana kunwa

    Kuchengetedzwa kunotarisana kana uchibata neTetrahydro-4-pyranol

    1. Kudzivirirwa Kwemunhu

    Kupfekedza zvipfeko zvakakodzera zvokudzivirira kuti usabatana zvakananga neTetrahydro-4-pyranol. Shandisa chiso chemasikati, magirazi ekuchengeteka, uye mupfuri wakagadzirwa nemafuta ekuchenesa mweya. Nekudzivirirwa kweganda, pfeka sutu yakakwana kusanganisira zvipfeko zvakakura zvehombodo uye magirasi asingadziviriri.

    2. Tetrahydro-4-pyranol (2081-44-9) Engineering Controls

    Iva nechokwadi kuti laboratori yakagadzirirwa hofu, inopedza kuputika kwemhepo, fani, mafoni ekuchenesa mweya, zvidzimiso zvemoto, uye kuchengetedzwa kwemhepo.

    3. Kutanga Kubatsira Maitiro

    Eye contact

    Bvisa manotsi emakwenzi asati asvinura maziso nemvura yakawanda yemvura kwema 15 maminitsi.

    Inhalation

    Endesa uyo akabatwa kune imwe nzvimbo yakadzivirira. Panyaya yekufema kunetseka, itungamirire kupumha kwemaitiro. Tsvaka rubatsiro rwezvekurapa kana zviratidzo zvichiripo.

    Kubatana kweganda

    Bvisa chero zvipfeko zvakasvibiswa. Shamba nzvimbo yacho nemari yakawanda yemvura yakasviba uye isiri isina kubvisa. Ramba uchinge uchenesa nzvimbo yacho pamusana pe15 maminitsi.

    Kuisa

    Kana uchiri kungwarira, geza muromo zvakakwana kana kunwa mvura yakawandisa inenge hafu yefa. Bvunza chiremba kana zviitiko zvinoramba zvichiramba, kana munhu anenge atova asina kuziva.

    4. Paunoshandisa Tetrahydro-4-pyranol

    Kana ikemikari iri kushandiswa, funga zvinotevera:

    • Dzivisa kufema guruva, mhepo, mafesi, kana zvimwe zvinokonzera
    • Pfekai magetsi ekudzivirira maziso, chiso, uye muviri wose
    • Shanda mune hood hood
    • Iva nechokwadi kuti kune chekuchengetedza mvura inowanikwa
    • Imba yacho inofanira kuva nemhepo yakakwana

    5. Mushure mekushandisa

    Mushure mekushandisa Tetrahydro-4-pyranol, iva nechokwadi chekutora matanho pasi apa:

    • Dzingai zvisikwa zvipi nezvipi zvisina chinhu zvakakwana
    • Chengetedza chigadzirwa chakasara mumubhodhoro wakavharwa zvakasimba mukati pepakutanga yepakutanga
    • Chenesa nzvimbo yekushanda uye uchenese chero kupera
    • Geza zvakakwana zvipfeko zvakasvibiswa usati washandisa zvakare
    • Pamusana pehutano hwemunhu, shambidza maoko pakarepo

    6. Apo kunze kweKushandiswa

    Apo Tetrahydro-4-pyranol isiri kushandiswa, funga nezvemashoko akanyorwa pasi apa:

    • Iva nechokwadi chokuti chigadzirwa chacho chakavharwa
    • Chengetedza munzvimbo yakachena uye yakaoma
    • Nzvimbo yekuchengetedza nzvimbo inofanira kunge yakasviba zvakanaka

    7. Tetrahydro-4-pyranol (2081-44-9) Kuchengeta nekubata

    chengetedzo

    • Chengeta pasi pekudziya kwepasi
    • Chiremera chinotarisana nekupisa kana moto
    • Kuvhara iyo muvhara rakavharwa
    • Shandisa yekutanga girasi bhodhoro pakachengetedza

    kukurukurwa

    • Shandisa kemikari fume hood
    • Pfekai magetsi ekudzivirira
    • Shanda mune imwe nzvimbo yekunze kana mukamuri ine ventiro yakanyanya

    8. Tetrahydro-4-pyranol (2081-44-9) Mikana Dzakanganisa

    Fire control

    Pfekai michina yekudzivirira paunenge uchidzima murazvo kuti udzivise kuputika kwemhepo ine uturu kana mhepo. Iyo michina yakatsva inogona kuva inotyisa kusvika kumapfupa ekufema apo inhaled. Shandisa kabhoni dioxide, purovu, kana yakaoma makemikari powder kuti udzimise moto.

    Spillages

    Shandisa inert inoshandisa soda ash kutora spill. Kanda zvisikwa muvharo uye zvakanyorwa mubhodhoro usati wasisunungura kuti uende. Geza nzvimbo yacho uye ventilate iyo.

    9. Tetrahydro-4-pyranol Yakasimba uye Reactivity

    Tetrahydro-4-pyranol inogadzikana mumvura. Inonyanya kupisa uye inogona kuparara kana ichiiswa kune kutonhora kwakanyanya, kupisa, mazhenje, kana mazhenje. Uyewo, haina kugadzikana pasi pesimba yakasimba ye-oxidizing, acid anhydrides, uye acid chloride.

    Kuparara kwezvinhu zvinosanganisira carbon dioxide uye carbon monoxide.

    10. Kurasikirwa Kwemakemikari

    Dzingai Tetrahydro-4-pyranol maererano nehurumende, nyika, kana misha mitemo yekurasika tsvina. Zvimwe, iwe unogona kuzvipisa muikemikisi incinerator, iyo inenge iine mushure mekutsva uye shrubber.

    11. (2081-44-9) Kutumira Mashoko

    Tetrahydro-4-pyranol (2081-44-9) Regulatory Info

    Chikumbaridzo cheTetrahydro-4-pyranol chiri mukati mezvinodiwa zveSARA Chitsauko III, zvikamu 302 uye 313. Uyezve, ruzivo rwekuchengeteka kwezvirongwa runotsanangurwa runopindirana nemitemo yeE EC hapana. 1907 / 2006.

    Tetrahydro-4-pyranol Technical Details

    Masayendisiti edu ane ruzivo mukutsvakurudza, chemikemikari, mararamiro uye masayenzi sayenzi, chromatography, uye analytical field.

    Tetrahydro-4-pyranol (2081-44-9) Kurayira Kukuru & Kutengo

    Kana uchida zvakawanda Tetrahydro-4-pyranol nokuda kwekutsvakurudza kwako, kukura, kushandura, kana chero imwe sarudzo, ita zvaunotarisana nesu.

    Bibliographie

    1. National Centre For Biotechnology Information, US. National Library Of Medicine, Pubchem, Tetrahydro-4-pyranol (2081-44-9) Zvikamu 1-8
    2. Chan, AW, et al. J. Med. Chem., 53, 3086 (2010); Desjardins, AE. et al .: Phytochem., 27, 767 (1988);
    3. David R. Lide, CRC Press,, 1995, Mazita, mazita, maonero, uye zvivako zvegumbeji, peji 234-278.

  2. Apicmo -

    Iyo yakanakisisa Tetrahydro-4-pyranol nebasa randakave narinazvo, Nice ruzivo

Add kudzokorora

Your kero e haangazozikamwi ichibudiswa.