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Yonghong Liang Ph.D. Chidimbu chehumbowo chemamiriro efundo ne kodzero

Yonghong Liang Ph.D. Chidimbu chehumbowo chemamiriro efundo ne kodzero

Maitiro makuru

Ongororo Yokutsvakurudza

  • Sep. 2006-iripo Kushanda kuP Ph.D (Organic Chemistry)
    Projects
    1. Chidzidzo cheongororo yekubatana pakati pe dapivirine (TMC120) uye HIV-1 reverse transcriptase
    2. Kuongororwa kwehupfumi-hukama hukama hutsva hweByylyl inonzi diarylpyrimidine
    3. Chigadziro, chidimbu uye SAR zvidzidzo zve α kana β naphthyl zvakashandurwa diarylpyrimidines sevasina nucleoside inhibitors zveHIV-1 reverse transcriptase
    4. Kugadzirwa uye kuenzaniswa kweDABOs semhando mbiri dzehutachiwana hweHIV-1 reverse transcriptase uye integrase

  • 2003-2006 Mudzidzisi
    Projects
    1. Ivhu-uye inofadza-state intramolecular proton kutumira kwa 2-hydroxybenzophenone, 8-hydroxy-4H-naphthalen-1-imwe, 5-hydroxy-4, 5-naphthoquinone, 1-hydroxy-9, 10-anthraquione, 7- Hydroxy -1-indenone, 5, 8-dihydroxy-1, 4-naphthoquinone), 4, 9-dihydroxyperylene-3, 10-quinone uye hypocrellin A yakanga yakadzidziswa nenzira dzedzidziso.
    2. Ivhu-iyo inermolecular proton inoshandiswa mumatambudziko e5-hydroxyisoxazole-mvura, DNA (RNA) seder dimer uye nheyo-N-methylformamide yakaitwa nemaitiro eDFT.
    2002-2003 Chiyero chekugadzirisa-chivako ukama pane physicochemical property ye ketone uye aldehyde

Awards

Hunan Province Purezidheni Mudzidzisi, 2008

Publications

1. Liang, YH; Chen, FE ONIOM DFT / PM3 kuverenga pamusoro pekubatana pakati pemapipirinine neHIV-1 reverse transcriptase, inoretical study. Drug Discov. Ther. 2007, 1, 57-60.

2. Liang, YH; Chen, FE QSAR zvidzidzo zve diarylpyrimidines inopesana neHIV-1 reverse transcriptase mhando-mhuka uye mutant strains. Eur. J. Med. Chem. 2009, 44, 625-631

3. Liang, YH; Feng, XQ; Zeng, ZS; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Design, Synthesis, uye SAR yaNaphthyl-Substituted Diarylpyrimidines seNi-Nucleoside Inhibitors yeHIV-1 Reverse Transcriptase. ChemMedChem 2009, 4, 1537-1545.

4. Feng, XQ; Liang, YH; Zeng, ZS; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Structural Kugadziriswa kweDAPY Analogues neKukonzera Anti-HIV-1 Activity. ChemMedChem 2009, 4, 219.

5. Zeng, ZS; Liang, YH; Feng, XQ; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Lead optimization ye diarylpyrimidines se inhibitors yevasina nucleoside HIV-1 reverse transcriptase, ChemMedChem 2010, yakagamuchirwa.

6. Liang, YH; Yi, PG Zvidzidzo zveongororwo pamusoro pekugadzirisa, simba uye intramolecular proton kutumirwa kwe alkannin. Chemistry Physics Letters, 2007, 438, 173.

7. Liang, YH; Yi, PG; Peng, HL Dzidziso yekushongedza, simba uye intramolecular hydrogen kutumirwa kwe hypocrellin A. Kemikirwo yeMikirini yePhysics, 2008, 466, 6-10.

8. Liang, YH; Yi, PG. Cao, CZ Chidzidzo cheongorori pamusoro pekushandiswa kweproton kunobatsira mu 5-hydroxyisoxazole. Zvinyorwa zveMolocular Structure: Theochem, 2005, 729, 163-167.

9. Yi, PG ;; Liang, YH; Cao, CZ Purotoni yeprotamolecular kana hydrogen-atomu inotenderera pasi uye nyika dzinofadza dze2-hydroxybenzophenone: A Theorytical Study. Chimiro Physics, 2005, 319, 297.

10. Yi, PG ;; Liang, YH Zvidzidzo zvekugadzirisa uye kugadzirisa zvinokonzerwa nekutenderera kweprotamolecular proton muvhu uye nyika dzinofadza. Chimiro Physics, 2006, 322, 382.

11. Yi, PG ;; Liang, YH Tang, ZQ Dzidzo yekuongorora ye intermolecular proton transfration reaction mune imwe nzvimbo yega 5-hydroxyisoxazole-water complexes. Chemhemia Physics, 2006, 2006, 322, 387.

12. Liang, YH; Zeng, ZS; Feng, XQ; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Parallel Synthesis uye Biological Kuongorora kweDiarylpyrimidines neMusimba Anorwisa HIV-1 Basa. Med. Chem. 2010, 18 (13), 4601.

13. Liang, YH; Zeng, ZS; Feng, XQ; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Kugadzirwa kweDABOs semhando mbiri inhibitor yeHIV-1 reverse transcriptase uye integrase. J. Med. Chem.

14. Chen, FE, Liang, YH Kufambira Mberi Kwakaitika Panyaya Inorwisa Anti-AIDS Zvinodhaka, Kubudirira muMishonga Chemakemikari (8), Peng, SQ Ed., 2011, 167.

15. Chen, FE, Liang, YH, Zeng, ZS PCT / CN2009 / 075931.

16. Zeng, ZS, Liang, YH, Zhang, JY, Xiong, JC China Patent ,, CN201110070027.4

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